Stimulation of Lipolysis and the Inhibition of Adipogenesis with AOD-9604

Journal Context: Journal of Endocrinology | Identifiers: DOI: 10.1677/joe.0.1630119 / PMID: 10741214

Principal Investigators: Ng, F. M., Jiang, W. J., Gianello, R., Pitt, M. J., & Roupas, P. (Monash University, Victoria, Australia)

Methodology: In vitro and ex vivo tracking utilizing isolated human and rodent adipocytes (fat cells). Tissues were treated with synthetic hGH C-terminal fragments to measure real-time glycerol release (the marker for fat breakdown) and monitor the accumulation of intracellular triglycerides.

Key Findings: Treating fat cells with the 176–191 fragment triggered a rapid, intense surge in lipolysis (fat burning), while concurrently blocking lipogenesis (the absorption of new fat molecules into cells). The fragment successfully mimicked the fat-burning potency of the full hGH molecule but showed a complete absence of the structural properties that trigger systemic insulin resistance, allowing the cells to empty their fat stores safely.