SS-31 + MOTS-c – 10mg / 10mg (3ml Pen)
Two mitochondrial compounds acting on different layers of the same biology — membrane structure and mitokine signalling. Research use only.
Mitochondrial Function
Mitokine Signalling
Cellular Energy
Description
This pairing brings together the two most-studied compounds in mitochondrial peptide research, chosen for mechanistic separation rather than overlap. SS-31 acts structurally, on the inner membrane lipid that organises the respiratory chain. MOTS-c acts as a signal, influencing nuclear gene expression and metabolic pathway activity. One addresses the machinery; the other addresses its regulation. The two are not documented to share a pathway, which is the entire basis for pairing them.
Mechanisms of Action
The combination pairs a structural and a signalling mechanism. Research describes SS-31 concentrating in the inner mitochondrial membrane and binding cardiolipin, stabilising cristae architecture and improving electron transport efficiency. MOTS-c is described as a mitochondrially encoded peptide that translocates to the nucleus under metabolic stress, activating AMPK signalling with downstream effects on glucose uptake and fatty acid oxidation. The two act on distinct layers of mitochondrial biology and are not documented to share a pathway.
Research Status & Findings
Both constituents have credible individual literatures, SS-31 including randomised clinical trials. Research on the specific combination has not been published.
SS-31 clinical data
Randomised controlled research in mitochondrial myopathy and cardiac populations.
MOTS-c research
Preclinical work on AMPK activation and metabolic endpoints in rodent models.
Mechanistic separation
Structural membrane stabilisation and nuclear signalling represent distinct layers.
Combination evidence
No published research examines the paired combination.
Evidence asymmetry
The two constituents differ considerably in the maturity of their evidence bases.
*For research purposes only – not for human consumption*
As Seen In The Press
Peptides can affect the way the body functions at a cellular level.
Our 3 Step System
Pre-filled Cartridges
Engineered for absolute accuracy and ease. Our pre-blended pens make precise dosing completely seamless in just three quick steps.
Step 1 - Remove the Pre-mixed pen from the box
Step 2 - Secure the needle tip
Step 3 - Twist to set the required dose
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